7yu8

Electron Microscopy
5.6Å resolution

Human Lysophosphatidic Acid Receptor 1-Gi complex bound to ONO-0740556, state4

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-225685 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Lysophosphatidic acid receptor 1 Chain: R
Molecule details ›
Chain: R
Length: 379 amino acids
Theoretical weight: 42.94 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q92633 (Residues: 2-364; Coverage: 100%)
Gene names: EDG2, LPA1, LPAR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.42 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
scFv16 Chain: S

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 5.6Å
Relevant EMDB volumes: EMD-34102
Expression system: Baculovirus expression vector pFastBac1-HM