› 7yxb

X-ray diffraction
2.1Å resolution

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Released:
DOI: 10.2210/pdb7yxb/pdb
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PDB entry 7yxb coloured by chain, front view.
PDB entry 7yxb coloured by chain, side view.
PDB entry 7yxb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous ET, Stolzenberg S, Sticht J, Wieczorek M, Roske Y, Günther M, Dähn S, Boesen BB, Calvo MM, Biese C, Kuppler F, Medina-García Á, Álvaro-Benito M, Höfer T, Noé F, Freund C
OpenAccess logo Nat Chem Biol (2023)
PMID: 37142807

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-268986 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 192 amino acids
Theoretical weight: 22.21 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: P01903 (Residues: 26-216; Coverage: 83%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 198 amino acids
Theoretical weight: 23.19 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: A0A1V1IGJ9 (Residues: 31-227; Coverage: 83%)
Gene name: HLA-DRB1
Sequence domains:
Class-II-associated invariant chain peptide Chains: G, H

Ligands and Environments

2 bound ligands:
Ligand EDO 16 x EDO
Ligand FLC 2 x FLC
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: C2221
Unit cell:
a: 96.891Å b: 111.485Å c: 212.54Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.222
Expression system: Baculovirus expression vector pFastBac1-HM

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Citations

1 review citation

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.
Lenz TL. (2024)
2 other articles

1 mention without citation

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.
Abualrous et al. (2023)

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