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› 7zdt

Electron Microscopy
2.71Å resolution

Occ(apo/return) conformation of CydDC mutant (E500Q.C) in ATP(CydC) bound state (Dataset-18)

Released:
DOI: 10.2210/pdb7zdt/pdb
PDB entry 7zdt coloured by chain, front view.
PDB entry 7zdt coloured by chain, side view.
PDB entry 7zdt coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Dissecting the conformational complexity and mechanism of a bacterial heme transporter.
Wu D, Mehdipour AR, Finke F, Goojani HG, Groh RR, Grund TN, Reichhart TMB, Zimmermann R, Welsch S, Bald D, Shepherd M, Hummer G, Safarian S
OpenAccess logo Nat Chem Biol 19 992-1003 (2023)
PMID: 37095238
Related structures: EMD-14669

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210868 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutathione/L-cysteine transport system ATP-binding/permease protein CydC Chain: C
Molecule details ›
Chain: C
Length: 573 amino acids
Theoretical weight: 62.98 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P23886 (Residues: 1-573; Coverage: 100%)
Gene names: JW0869, b0886, cydC, mdrA, mdrH, surB
Sequence domains:
Glutathione/L-cysteine transport system ATP-binding/permease protein CydD Chain: D
Molecule details ›
Chain: D
Length: 588 amino acids
Theoretical weight: 65.12 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P29018 (Residues: 1-588; Coverage: 100%)
Gene names: JW0870, b0887, cydD, htrD
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.71Å
Relevant EMDB volumes: EMD-14669
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

Structural aspects of enzymes involved in prokaryotic Gram-positive heme biosynthesis.
Falb et al. (2023)