We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 7zej

X-ray diffraction
1.79Å resolution

Crystal structure of the human MGC45594 gene product in complex with celecoxib.

Released:
DOI: 10.2210/pdb7zej/pdb
Model geometry
Fit model/data
PDB entry 7zej coloured by chain, front view.
PDB entry 7zej coloured by chain, side view.
PDB entry 7zej coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Shafqat N, Yue WW, Koekemoer L, Niesen F, Ugochukwu E, Vollmar M, Weigelt J, Krojer T, Pike A, Chaikaud A, Von Delft F, Arrowsmith C, Bountra C, Edwards A, Opperman U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1) 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandinE2 + NADPH + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin reductase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 36.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N4Q0 (Residues: 33-371; Coverage: 90%)
Gene names: PTGR3, ZADH2
Sequence domains:

Ligands and Environments


Cofactor: Ligand NAP 2 x NAP
1 bound ligand:
Ligand CEL 2 x CEL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 46.83Å b: 51.41Å c: 75.88Å
α: 93.86° β: 91.48° γ: 101.29°
R-values:
R R work R free
0.186 0.185 0.234
Expression system: Escherichia coli

Quick links