› 7zgk

Electron Microscopy
3.59Å resolution

Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b

Released:
DOI: 10.2210/pdb7zgk/pdb
PDB entry 7zgk coloured by chain, front view.
PDB entry 7zgk coloured by chain, side view.
PDB entry 7zgk coloured by chain, top view.
Source organisms:
Primary publication:
Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Sülzen H, Began J, Dhillon A, Kereïche S, Pompach P, Votrubova J, Zahedifard F, Šubrtova A, Šafner M, Hubalek M, Thompson M, Zoltner M, Zoll S
OpenAccess logo Nat Commun 14 2403 (2023)
PMID: 37105991
Related structures: EMD-14708

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-270120 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C3 beta chain Chain: A
Molecule details ›
Chain: A
Length: 645 amino acids
Theoretical weight: 71.39 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-667; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Complement C3b Chain: B
Molecule details ›
Chain: B
Length: 915 amino acids
Theoretical weight: 104.07 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-1663; Coverage: 56%)
Gene names: C3, CPAMD1
Sequence domains:
65 kDa invariant surface glycoprotein, putative Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.59Å
Relevant EMDB volumes: EMD-14708
Expression system: Escherichia coli

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Citations

2 review citations

Predictive modeling and cryo-EM: A synergistic approach to modeling macromolecular structure.
Corum et al. (2024)
1 more