› 7zpg

X-ray diffraction
1.16Å resolution

CRYSTAL STRUCTURE OF HUMAN MONOGLYCERIDE LIPASE WITH LIGAND

Released:
DOI: 10.2210/pdb7zpg/pdb
PDB entry 7zpg coloured by chain, front view.
PDB entry 7zpg coloured by chain, side view.
PDB entry 7zpg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature.
Kemble AM, Hornsperger B, Ruf I, Richter H, Benz J, Kuhn B, Heer D, Wittwer M, Engelhardt B, Grether U, Collin L
PLoS One 17 e0268590 (2022)
PMID: 36084029

Function and Biology Details

Reaction catalysed: 
Hydrolyzes glycerol monoesters of long-chain fatty acids
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Monoglyceride lipase Chain: A
Molecule details ›
Chain: A
Length: 323 amino acids
Theoretical weight: 35.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99685 (Residues: 1-303; Coverage: 100%)
Gene name: MGLL
Sequence domains: Serine aminopeptidase, S33

Ligands and Environments

1 bound ligand:
Ligand JQX 1 x JQX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 91.884Å b: 127.43Å c: 60.461Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.176 0.184
Expression system: Escherichia coli

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