› 7zuc

X-ray diffraction
1.89Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-233870 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O78126 (Residues: 22-297; Coverage: 81%)
Gene name: MHC class I HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
LEU-LEU-LEU-GLY-ILE-GLY-ILE-LEU-VAL Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 910 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3212
Unit cell:
a: 85.259Å b: 85.259Å c: 213.486Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.212 0.247
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Advances in tumor immunomodulation based on nanodrug delivery systems.
Wang et al. (2023)
2 more