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› 8ag1

X-ray diffraction
3.3Å resolution

Crystal structure of a novel OX40 antibody

Released:
DOI: 10.2210/pdb8ag1/pdb
Model geometry
Fit model/data
PDB entry 8ag1 coloured by chain, front view.
PDB entry 8ag1 coloured by chain, side view.
PDB entry 8ag1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Zhang J, Jiang X, Gao H, Zhang F, Zhang X, Zhou A, Xu T, Cai H
OpenAccess logo Biomolecules 12 (2022)
PMID: 36139048

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273776 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Novel OX40 antibody light chain Chains: L, l
Molecule details ›
Chains: L, l
Length: 216 amino acids
Theoretical weight: 23.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Novel OX40 antibody heavy chain Chains: H, h
Molecule details ›
Chains: H, h
Length: 240 amino acids
Theoretical weight: 26.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Tumor necrosis factor receptor superfamily member 4 Chains: A, a

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P6222
Unit cell:
a: 162.356Å b: 162.356Å c: 232.145Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.194 0.268
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer.
Mahasongkram et al. (2023)

1 mention without citation

Structural Basis of a Novel Agonistic Anti-OX40 Antibody.
Zhang et al. (2022)