› 8axc

X-ray diffraction
2.12Å resolution

Function and Biology Details

Reaction catalysed: 
O-acylcarnitine + H(2)O = a fatty acid + L-carnitine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acylcarnitine hydrolase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 561 amino acids
Theoretical weight: 62.53 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91WG0 (Residues: 1-561; Coverage: 100%)
Gene names: Ces2, Ces2c
Sequence domains: Carboxylesterase family

Ligands and Environments

3 bound ligands:
Ligand CL 4 x CL
Ligand NCA 6 x NCA
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P212121
Unit cell:
a: 98.052Å b: 143.595Å c: 183.756Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.163 0.196
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Potential herb‒drug interactions between anti-COVID-19 drugs and traditional Chinese medicine.
Ye et al. (2023)

1 mention without citation

The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1.
Eisner et al. (2022)