› 8ayh

Electron Microscopy
3.35Å resolution

Structure of Complement C5 in Complex with small molecule inhibitor and CVF

Released:
DOI: 10.2210/pdb8ayh/pdb
PDB entry 8ayh coloured by chain, front view.
PDB entry 8ayh coloured by chain, side view.
PDB entry 8ayh coloured by chain, top view.
Source organisms:
Primary publication:
A small-molecule inhibitor of C5 complement protein.
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, McLaughlin D, Be C, Wiesmann C, Murphy J, Bolduc P, Mogi M, Duca J, Namil A, Capparelli M, Darsigny V, Meredith E, Tichkule R, Ferrara L, Heyder J, Liu F, Horton PA, Romanowski MJ, Schirle M, Mainolfi N, Anderson K, Michaud GA
Nat Chem Biol 15 666-668 (2019)
PMID: 31209353
Related structures: EMD-15713

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133862 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Complement C5 beta chain Chain: C
Molecule details ›
Chain: C
Length: 657 amino acids
Theoretical weight: 73.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01031 (Residues: 19-675; Coverage: 40%)
Gene names: C5, CPAMD4
Sequence domains:
Complement C5 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 999 amino acids
Theoretical weight: 112.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01031 (Residues: 678-1676; Coverage: 60%)
Gene names: C5, CPAMD4
Sequence domains:
Cobra venom factor Chain: B
Molecule details ›
Chain: B
Length: 1642 amino acids
Theoretical weight: 184.73 KDa
Source organism: Naja kaouthia
UniProt:
  • Canonical: Q91132 (Residues: 1-1642; Coverage: 100%)
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand H1H 1 x H1H
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.35Å
Relevant EMDB volumes: EMD-15713

Quick links

Citations

5 review citations

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches.
Jin et al. (2020)
4 more