› 8b78

X-ray diffraction
1.11Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase KRas, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 19.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01116 (Residues: 1-164; Coverage: 87%)
Gene names: KRAS, KRAS2, RASK2
Sequence domains: Ras family

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
Ligand PUO 1 x PUO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: R32
Unit cell:
a: 94.36Å b: 94.36Å c: 122.47Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.224 0.236
Expression system: Escherichia coli

Quick links

Citations

1 review citation

KRASG12C Inhibitors in Non-Small Cell Lung Cancer: A Review.
Tang et al. (2024)
1 other article