› 8blo

Electron Microscopy
2.9Å resolution

Human Urea Transporter UT-A (N-Terminal Domain Model)

Released:
DOI: 10.2210/pdb8blo/pdb
PDB entry 8blo coloured by chain, front view.
PDB entry 8blo coloured by chain, side view.
PDB entry 8blo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
Chi G, Dietz L, Tang H, Snee M, Scacioc A, Wang D, Mckinley G, Mukhopadhyay SMM, Pike ACW, Chalk R, Burgess-Brown NA, Timmermans JP, van Putte W, Robinson CV, Dürr KL
Sci Adv 9 eadg8229 (2023)
PMID: 37774028
Related structures: EMD-16110

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-231361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urea transporter 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 910 amino acids
Theoretical weight: 100.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15849 (Residues: 1-903; Coverage: 98%)
Gene names: HUT2, SLC14A2, UT2
Sequence domains: Urea transporter

Ligands and Environments

2 bound ligands:
Ligand PLD 9 x PLD
Ligand LMN 15 x LMN
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-16110
Expression system: Homo sapiens

Quick links

Citations

1 mention without citation

Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
Chi et al. (2023)