› 8bnq

X-ray diffraction
2.3Å resolution

Crystal structure of the FnIII-tandem A84-A86 from the A-band of titin

Released:
DOI: 10.2210/pdb8bnq/pdb
PDB entry 8bnq coloured by chain, front view.
PDB entry 8bnq coloured by chain, side view.
PDB entry 8bnq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insights into titin's A-band.
Fleming JR, Müller I, Zacharchenko T, Diederichs K, Mayans O
J Muscle Res Cell Motil (2023)
PMID: 37258982

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 33.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZ42 (Residues: 23562-23862; Coverage: 1%)
Gene name: TTN
Sequence domains: Fibronectin type III domain

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 31.27Å b: 75Å c: 79.84Å
α: 114.574° β: 92.503° γ: 100.913°
R-values:
R R work R free
0.2 0.198 0.258
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Molecular insights into titin's A-band.
Fleming et al. (2023)