› 8cir

X-ray diffraction
1.85Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150638 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Moesin Chains: A, B
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 41.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P26038 (Residues: 1-346; Coverage: 60%)
Gene name: MSN
Sequence domains:
C3P Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 amino acids
Theoretical weight: 1.76 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand BR 15 x BR
Ligand EDO 9 x EDO
Ligand B3P 2 x B3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 45.466Å b: 155.391Å c: 63.607Å
α: 90° β: 94.28° γ: 90°
R-values:
R R work R free
0.179 0.178 0.241
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

1 review citation

Fused Tetrahydroquinolines Are Interfering with Your Assay.
Bashore et al. (2023)

1 mention without citation

Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Du et al. (2023)