We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 8cno

X-ray diffraction
1.75Å resolution

Improved complex structure of human Sirtuin 6 with its inhibitor cis-resveratrol

Released:
DOI: 10.2210/pdb8cno/pdb
Model geometry
Fit model/data
PDB entry 8cno coloured by chain, front view.
PDB entry 8cno coloured by chain, side view.
PDB entry 8cno coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: You W, Steegborn C

Function and Biology Details

Reaction catalysed: 
[N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose+ nicotinamide + L-lysyl-[protein]., N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose+ nicotinamide + L-lysyl-[protein].]
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NAD-dependent protein deacylase sirtuin-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 33.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8N6T7 (Residues: 13-308; Coverage: 83%)
Gene names: SIR2L6, SIRT6
Sequence domains: Sir2 family

Ligands and Environments

9 bound ligands:
Ligand AR6 2 x AR6
Ligand ZN 2 x ZN
Ligand STL 2 x STL
Ligand PG4 1 x PG4
Ligand EDO 2 x EDO
Ligand SO4 9 x SO4
Ligand CL 6 x CL
Ligand PEG 1 x PEG
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P63
Unit cell:
a: 91.276Å b: 91.276Å c: 143.23Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.167 0.188
Expression system: Escherichia coli BL21(DE3)

Quick links