› 8cv4

X-ray diffraction
1.93Å resolution

Peptide 4.2C in complex with BRD4.2

Released:
DOI: 10.2210/pdb8cv4/pdb
Model geometry
Fit model/data
PDB entry 8cv4 coloured by chain, front view.
PDB entry 8cv4 coloured by chain, side view.
PDB entry 8cv4 coloured by chain, top view.
Source organisms:
Primary publication:
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Franck C, Patel K, Walport LJ, Christie M, Norman A, Passioura T, Suga H, Payne RJ, Mackay JP
Structure 31 912-923.e4 (2023)
PMID: 37269828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero trimer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271786 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 122 amino acids
Theoretical weight: 14.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 347-464; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Peptide 4.2F Chains: C, D, E
Molecule details ›
Chains: C, D, E
Length: 12 amino acids
Theoretical weight: 1.77 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ACE 3 x ACE
Ligand NH2 3 x NH2
1 modified residue:
Ligand ALY 6 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 53.575Å b: 65.855Å c: 76.395Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.254
Expression systems:
  • Escherichia coli
  • Not provided

Quick links