› 8cv6

X-ray diffraction
1.7Å resolution

Peptide 4.2B in complex with BRD4.2

Released:
DOI: 10.2210/pdb8cv6/pdb
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PDB entry 8cv6 coloured by chain, front view.
PDB entry 8cv6 coloured by chain, side view.
PDB entry 8cv6 coloured by chain, top view.
Source organisms:
Primary publication:
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Franck C, Patel K, Walport LJ, Christie M, Norman A, Passioura T, Suga H, Payne RJ, Mackay JP
Structure 31 912-923.e4 (2023)
PMID: 37269828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271788 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 347-464; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Peptide 4.2E Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 2.23 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ACE 1 x ACE
Ligand NH2 1 x NH2
1 modified residue:
Ligand ALY 3 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 29.442Å b: 59.636Å c: 36.269Å
α: 90° β: 100.606° γ: 90°
R-values:
R R work R free
0.183 0.181 0.222
Expression systems:
  • Escherichia coli
  • Not provided

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