› 8cv7

X-ray diffraction
1.6Å resolution

Peptide 2.2E in complex with BRD2-BD2

Released:
DOI: 10.2210/pdb8cv7/pdb
Model geometry
Fit model/data
PDB entry 8cv7 coloured by chain, front view.
PDB entry 8cv7 coloured by chain, side view.
PDB entry 8cv7 coloured by chain, top view.
Source organisms:
Primary publication:
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Franck C, Patel K, Walport LJ, Christie M, Norman A, Passioura T, Suga H, Payne RJ, Mackay JP
Structure 31 912-923.e4 (2023)
PMID: 37269828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273443 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 13.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 347-455; Coverage: 14%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Peptide 2.2E Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.7 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ACE 2 x ACE
Ligand NH2 2 x NH2
1 modified residue:
Ligand ALY 4 x ALY

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 52.948Å b: 52.42Å c: 55.993Å
α: 90° β: 96.674° γ: 90°
R-values:
R R work R free
0.176 0.174 0.198
Expression systems:
  • Escherichia coli
  • Not provided

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