Function and Biology Details
Reactions catalysed:
SsDNA + n NTP = ssDNA/pppN(pN)(n-1) hybrid + (n-1) diphosphate
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA-directed DNA polymerase, family B
- Nucleic acid-binding, OB-fold
- DNA polymerase alpha, subunit B
- DNA primase large subunit, eukaryotic/archaeal
- DNA primase, small subunit, eukaryotic/archaeal
- CST complex subunit Ten1, animal and plant type
- DNA polymerase alpha/delta/epsilon, subunit B
- DNA polymerase alpha, subunit B, N-terminal
21 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
DNA polymerase alpha:primase complex and DNA (preferred)
PDBe Complex ID:
PDB-CPX-270350 (preferred)
Entry contents:
7 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct DNA molecule
Macromolecules (8 distinct):
CST complex subunit CTC1
Molecule details ›
Chain: A
Length: 1209 amino acids
Theoretical weight: 133.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: CST, telomere maintenance, complex subunit CTC1
Length: 1209 amino acids
Theoretical weight: 133.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
Q2NKJ3 (Residues: 9-1217; Coverage: 99%)
Sequence domains: CST, telomere maintenance, complex subunit CTC1
CST complex subunit STN1
Molecule details ›
Chain: B
Length: 362 amino acids
Theoretical weight: 41.59 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 362 amino acids
Theoretical weight: 41.59 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: Q9H668 (Residues: 7-368; Coverage: 98%)
Sequence domains:
CST complex subunit TEN1
DNA primase small subunit
DNA primase large subunit
DNA polymerase alpha catalytic subunit
DNA polymerase alpha subunit B
