› 8d3c

Electron Microscopy
3.1Å resolution

VWF tubule derived from monomeric D1-A1

Released:
DOI: 10.2210/pdb8d3c/pdb
PDB entry 8d3c coloured by chain, front view.
PDB entry 8d3c coloured by chain, side view.
PDB entry 8d3c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.
Anderson JR, Li J, Springer TA, Brown A
OpenAccess logo Blood (2022)
PMID: 35776905
Related structures: EMD-27156

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272258 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
von Willebrand factor Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 1469 amino acids
Theoretical weight: 162.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P04275 (Residues: 1-1464; Coverage: 52%)
Gene names: F8VWF, VWF
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CA 48 x CA
Ligand NAG 80 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-27156
Expression system: Homo sapiens

Quick links

Citations

1 review citation

The Prothrombin-Prothrombinase Interaction.
Stojanovski et al. (2024)
7 other articles

2 mentions without citation

Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange.
Anderson et al. (2022)
1 more