Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Fibronectin type III
- Immunoglobulin-like fold
- Fibronectin type III superfamily
- Four-helical cytokine-like, core
- Interleukin-27 alpha
- Long hematopoietin receptor, soluble alpha chain, conserved site
- Long hematopoietin receptor, Gp130 family 2, conserved site
- Type I cytokine receptor, cytokine-binding domain
1 more domain
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Interleukin-27 receptor-ligand complex (preferred)
PDBe Complex ID:
PDB-CPX-154045 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Interleukin-27 subunit beta
Molecule details ›
Chain: C
Length: 209 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Fibronectin type III domain
Length: 209 amino acids
Theoretical weight: 23.34 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
Q14213 (Residues: 21-229; Coverage: 100%)
Sequence domains: Fibronectin type III domain
Interleukin-27 subunit alpha
Molecule details ›
Chain: D
Length: 243 amino acids
Theoretical weight: 27.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Length: 243 amino acids
Theoretical weight: 27.88 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: Q8NEV9 (Residues: 29-243; Coverage: 100%)
Interleukin-27 receptor subunit alpha
Interleukin-6 receptor subunit beta
