› 8dhm

Electron Microscopy
2.73Å resolution

Human TMEM175 in complex with 4-aminopyridine

Released:
DOI: 10.2210/pdb8dhm/pdb
PDB entry 8dhm coloured by chain, front view.
PDB entry 8dhm coloured by chain, side view.
PDB entry 8dhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Oh S, Stix R, Zhou W, Faraldo-Gómez JD, Hite RK
Proc Natl Acad Sci U S A 119 e2208882119 (2022)
PMID: 36279431
Related structures: EMD-27436

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endosomal/lysosomal proton channel TMEM175 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Sequence domains: Endosomal/lysosomal potassium channel TMEM175

Ligands and Environments

2 bound ligands:
Ligand K 4 x K
Ligand 4AP 1 x 4AP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.73Å
Relevant EMDB volumes: EMD-27436
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Advances in Drug Discovery Targeting Lysosomal Membrane Proteins.
Wang et al. (2023)
1 more

1 mention without citation

Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Oh et al. (2022)