› 8dyg

X-ray diffraction
1.49Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172495 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-17A Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16552 (Residues: 34-155; Coverage: 92%)
Gene names: CTLA8, IL17, IL17A
Sequence domains: Interleukin-17

Ligands and Environments

1 bound ligand:
Ligand U5Q 2 x U5Q
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 170.036Å b: 35.819Å c: 45.509Å
α: 90° β: 98.23° γ: 90°
R-values:
R R work R free
0.212 0.211 0.233
Expression system: Escherichia coli

Quick links

Citations

1 review citation

New and Emerging Oral/Topical Small-Molecule Treatments for Psoriasis.
Carmona-Rocha et al. (2024)
1 other article

1 mention without citation

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Goedken et al. (2022)