› 8eob

Electron Microscopy
3.1Å resolution

Cryo-EM structure of human HSP90B in the closed state

Released:
DOI: 10.2210/pdb8eob/pdb
PDB entry 8eob coloured by chain, front view.
PDB entry 8eob coloured by chain, side view.
PDB entry 8eob coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023)
PMID: 36657440
Related structures: EMD-28333

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 756 amino acids
Theoretical weight: 87.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08238 (Residues: 2-724; Coverage: 100%)
Gene names: HSP90AB1, HSP90B, HSPC2, HSPC3, HSPCB
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 2 x ANP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-28333
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Reconstitution of the phosphodiesterase 6 maturation process important for photoreceptor cell function.
Singh et al. (2024)
1 more

3 mentions without citation

Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Srivastava et al. (2023)
2 more