› 8eor

Electron Microscopy
2.67Å resolution

Liver carboxylesterase 1

Released:
DOI: 10.2210/pdb8eor/pdb
PDB entry 8eor coloured by chain, front view.
PDB entry 8eor coloured by chain, side view.
PDB entry 8eor coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structural-omics of human liver enzymes.
Su CC, Lyu M, Zhang Z, Miyagi M, Huang W, Taylor DJ, Yu EW
Cell Rep 42 112609 (2023)
PMID: 37289586
Related structures: EMD-23427, EMD-28465

Function and Biology Details

Reactions catalysed: 
A carboxylic ester + H(2)O = an alcohol + a carboxylate
A steryl ester + H(2)O = a sterol + a fatty acid
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Liver carboxylesterase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 567 amino acids
Theoretical weight: 62.59 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P23141 (Residues: 1-567; Coverage: 100%)
  • Best match: P23141-2 (Residues: 1-568)
Gene names: CES1, CES2, SES1
Sequence domains: Carboxylesterase family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand EEE 3 x EEE
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.67Å
Relevant EMDB volumes: EMD-23427, EMD-28465

Quick links

Citations

1 citations in other articles

High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.
Zhang et al. (2023)