› 8epl

Electron Microscopy
3.1Å resolution

Human R-type voltage-gated calcium channel Cav2.3 at 3.1 Angstrom resolution

Released:
DOI: 10.2210/pdb8epl/pdb
PDB entry 8epl coloured by chain, front view.
PDB entry 8epl coloured by chain, side view.
PDB entry 8epl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments.
Yao X, Wang Y, Wang Z, Fan X, Wu D, Huang J, Mueller A, Gao S, Hu M, Robinson CV, Yu Y, Gao S, Yan N
OpenAccess logo Nat Commun 13 7358 (2022)
PMID: 36446785
Related structures: EMD-28529

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156983 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Voltage-dependent R-type calcium channel subunit alpha-1E Chain: A
Molecule details ›
Chain: A
Length: 2313 amino acids
Theoretical weight: 262.06 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q15878 (Residues: 1-2313; Coverage: 100%)
Gene names: CACH6, CACNA1E, CACNL1A6
Sequence domains:
Voltage-dependent L-type calcium channel subunit beta-3 Chain: B
Molecule details ›
Chain: B
Length: 484 amino acids
Theoretical weight: 54.61 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P54284 (Residues: 1-484; Coverage: 100%)
Gene names: CACNB3, CACNLB3
Sequence domains:
Voltage-dependent calcium channel subunit alpha-2/delta-1 Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand CA 2 x CA
Ligand CLR 5 x CLR
Ligand 3PE 2 x 3PE
Ligand PT5 1 x PT5
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-28529
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Pathology of pain and its implications for therapeutic interventions.
Cao et al. (2024)
4 more

1 mention without citation

Structural biology of voltage-gated calcium channels.
Yao et al. (2024)