Function and Biology Details
Reactions catalysed:
[protein]-peptidylproline (omega=180) = [protein]-peptidylproline(omega=0).
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+).
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154618 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1A
Molecule details ›
Chains: A, C, E
Length: 108 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Length: 108 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P62942 (Residues: 2-108; Coverage: 99%)
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Serine/threonine-protein kinase mTOR
Molecule details ›
Chains: B, D, F
Length: 95 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: FKBP12-rapamycin binding domain
Length: 95 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P42345 (Residues: 2019-2112; Coverage: 4%)
Sequence domains: FKBP12-rapamycin binding domain
