› 8esb

Electron Microscopy
3.12Å resolution

CryoEM structure of HLA-A2 bound to MAGEA8 (232-241) peptide

Released:
DOI: 10.2210/pdb8esb/pdb
PDB entry 8esb coloured by chain, front view.
PDB entry 8esb coloured by chain, side view.
PDB entry 8esb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM.
Saotome K, Dudgeon D, Colotti K, Moore MJ, Jones J, Zhou Y, Rafique A, Yancopoulos GD, Murphy AJ, Lin JC, Olson WC, Franklin MC
Nat Commun 14 2401 (2023)
PMID: 37100770
Related structures: EMD-28574

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig-like domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 448 amino acids
Theoretical weight: 50.31 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q53Z42 (Residues: 25-303; Coverage: 82%)
Gene name: HLA-A
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.12Å
Relevant EMDB volumes: EMD-28574
Expression system: Cricetulus griseus

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