8euq

X-ray diffraction
3.09Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-233081 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 188 amino acids
Theoretical weight: 21.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 28-206; Coverage: 78%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
c44H10 Fab light chain Chains: D, H
Molecule details ›
Chains: D, H
Length: 214 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Hemagglutinin HA1 chain; Ig-like domain-containing protein Chains: B, G
Molecule details ›
Chains: B, G
Length: 226 amino acids
Theoretical weight: 25.94 KDa
Source organisms: Expression system: Homo sapiens
UniProt:
  • Canonical: P04664 (Residues: 304-318; Coverage: 5%)
  • Canonical: A0A1V1IGJ9 (Residues: 30-219; Coverage: 80%)
Gene names: HA, HLA-DRB1
Sequence domains:
c44H10 Fab heavy chain Chains: C, I
Molecule details ›
Chains: C, I
Length: 223 amino acids
Theoretical weight: 23.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I222
Unit cell:
a: 169.15Å b: 178.72Å c: 182.04Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.244
Expression system: Homo sapiens