› 8f6z

Electron Microscopy
2.7Å resolution

Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state

Released:
DOI: 10.2210/pdb8f6z/pdb
PDB entry 8f6z coloured by chain, front view.
PDB entry 8f6z coloured by chain, side view.
PDB entry 8f6z coloured by chain, top view.
Source organism: Tetronarce californica
Primary publication:
Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
Goswami U, Rahman MM, Teng J, Hibbs RE
Nat Commun 14 3169 (2023)
PMID: 37264005
Related structures: EMD-28893

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136090 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (8 distinct):
Acetylcholine receptor subunit alpha Chains: A, D
Molecule details ›
Chains: A, D
Length: 433 amino acids
Theoretical weight: 49.77 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02710 (Residues: 25-457; Coverage: 99%)
Gene name: CHRNA1
Sequence domains:
Acetylcholine receptor subunit delta Chain: B
Molecule details ›
Chain: B
Length: 500 amino acids
Theoretical weight: 57.55 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02718 (Residues: 22-521; Coverage: 100%)
Gene name: chrnd
Sequence domains:
Acetylcholine receptor subunit beta Chain: C
Molecule details ›
Chain: C
Length: 469 amino acids
Theoretical weight: 53.73 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02712 (Residues: 25-493; Coverage: 100%)
Gene name: CHRNB1
Sequence domains:
Acetylcholine receptor subunit gamma Chain: E
Molecule details ›
Chain: E
Length: 489 amino acids
Theoretical weight: 56.34 KDa
Source organism: Tetronarce californica
UniProt:
  • Canonical: P02714 (Residues: 18-506; Coverage: 100%)
Gene name: CHRNG
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand SCK 2 x SCK
Ligand CLR 3 x CLR
Ligand NAG 2 x NAG
Ligand POV 5 x POV
Ligand DD9 1 x DD9
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-28893

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