› 8feg

Electron Microscopy
2.54Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-273698 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: C
Molecule details ›
Chain: C
Length: 354 amino acids
Theoretical weight: 40.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: D
Molecule details ›
Chain: D
Length: 358 amino acids
Theoretical weight: 39.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: E
scFv16 antibody fragment Chain: F
Kappa-type opioid receptor Chain: B
ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9 Chain: A

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DTY 1 x DTY
Ligand DPN 1 x DPN

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.54Å
Relevant EMDB volumes: EMD-29026
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

2 review citations

Peptide-Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics.
Dean et al. (2024)
1 more

1 mention without citation

Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development.
Li et al. (2024)