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Electron Microscopy
2.62Å resolution

Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein

Released:
Source organism: Homo sapiens
Primary publication:
J Pharmacol Exp Ther (2023)
PMID: 37643795
Related structures: EMD-29077

Function and Biology Details

Reaction catalysed:
Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Argand Arg-|-Ser bonds in (human) kininogen to release bradykinin.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-272237 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
STAR-0215 Light chain Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
STAR-0215 Heavy chain Chain: B
Molecule details ›
Chain: B
Length: 224 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Plasma kallikrein Chain: C

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.62Å
Relevant EMDB volumes: EMD-29077
Expression system: Cricetulus griseus