› 8fu4

X-ray diffraction
1.6Å resolution

HCMV US11 peptide binding to HLA-A*02:01

Released:
DOI: 10.2210/pdb8fu4/pdb
Model geometry
Fit model/data
PDB entry 8fu4 coloured by chain, front view.
PDB entry 8fu4 coloured by chain, side view.
PDB entry 8fu4 coloured by chain, top view.
Source organisms:
Primary publication:
Diverse cytomegalovirus US11 antagonism and MHC-A evasion strategies reveal a tit-for-tat coevolutionary arms race in hominids.
Zimmermann C, Watson GM, Bauersfeld L, Berry R, Ciblis B, Lan H, Gerke C, Oberhardt V, Fuchs J, Hofmann M, Freund C, Rossjohn J, Momburg F, Hengel H, Halenius A
Proc Natl Acad Sci U S A 121 e2315985121 (2024)
PMID: 38377192

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-279570 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q53Z42 (Residues: 25-299; Coverage: 81%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Unique short US11 glycoprotein Chain: C

Ligands and Environments

3 bound ligands:
Ligand GOL 2 x GOL
Ligand CD 1 x CD
Ligand PGE 1 x PGE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 59.874Å b: 79.27Å c: 110.664Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.18 0.204
Expression systems:
  • Escherichia coli BL21
  • synthetic construct

Quick links

Citations

1 citations in other articles

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning.
Gerke et al. (2024)