› 8fyt

Electron Microscopy
2.64Å resolution

LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex

Released:
DOI: 10.2210/pdb8fyt/pdb
PDB entry 8fyt coloured by chain, front view.
PDB entry 8fyt coloured by chain, side view.
PDB entry 8fyt coloured by chain, top view.
Source organisms:
Primary publication:
Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D
Nature (2024)
PMID: 38720072
Related structures: EMD-29597

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-140422 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
5-hydroxytryptamine receptor 1A; Soluble cytochrome b562 Chain: R
Molecule details ›
Chain: R
Length: 552 amino acids
Theoretical weight: 61.38 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 13-127; Coverage: 98%)
  • Canonical: P08908 (Residues: 26-422; Coverage: 94%)
Gene names: ADRB2RL1, ADRBRL1, HTR1A, cybC
Sequence domains:
Guanine nucleotide-binding protein G(i) subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 354 amino acids
Theoretical weight: 40.42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P63096 (Residues: 1-354; Coverage: 100%)
Gene name: GNAI1
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G

Ligands and Environments

3 bound ligands:
Ligand 7LD 1 x 7LD
Ligand J40 1 x J40
Ligand Y01 2 x Y01
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.64Å
Relevant EMDB volumes: EMD-29597
Expression system: Spodoptera frugiperda

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Citations

1 review citation

CCNP Innovations in Neuropsychopharmacology Award: The psychopharmacology of psychedelics: where the brain meets spirituality.
Gobbi G. (2024)
2 other articles

1 mention without citation

Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Warren et al. (2024)