› 8ga2

X-ray diffraction
1.85Å resolution

Bromodomain of CBP liganded with inhibitor iCBP5

Released:
DOI: 10.2210/pdb8ga2/pdb
Model geometry
Fit model/data
PDB entry 8ga2 coloured by chain, front view.
PDB entry 8ga2 coloured by chain, side view.
PDB entry 8ga2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition.
Shendy NAM, Bikowitz M, Sigua LH, Zhang Y, Mercier A, Khashana Y, Nance S, Liu Q, Delahunty IM, Robinson S, Goel V, Rees MG, Ronan MA, Wang T, Kocak M, Roth JA, Wang Y, Freeman BB, Orr BA, Abraham BJ, Roussel MF, Schonbrunn E, Qi J, Durbin AD
OpenAccess logo Nat Commun 15 3483 (2024)
PMID: 38664416

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187751 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-binding protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 116 amino acids
Theoretical weight: 13.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q92793 (Residues: 1082-1197; Coverage: 5%)
Gene names: CBP, CREBBP
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand YVK 4 x YVK
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 45.86Å b: 107.01Å c: 55.83Å
α: 90° β: 113.98° γ: 90°
R-values:
R R work R free
0.192 0.19 0.225
Expression system: Escherichia coli BL21(DE3)

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