› 8hbv

Electron Microscopy
2.51Å resolution

Structure of human UCP1 in the nucleotide-free state

Released:
DOI: 10.2210/pdb8hbv/pdb
PDB entry 8hbv coloured by chain, front view.
PDB entry 8hbv coloured by chain, side view.
PDB entry 8hbv coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Kang Y, Chen L
Nature (2023)
PMID: 37336486
Related structures: EMD-34644

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-276184 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitochondrial brown fat uncoupling protein 1 Chain: A
Molecule details ›
Chain: A
Length: 363 amino acids
Theoretical weight: 39.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P25874 (Residues: 1-307; Coverage: 100%)
Gene names: SLC25A7, UCP, UCP1
Sequence domains: Mitochondrial carrier protein
Sybody 12F2 Chain: B
Molecule details ›
Chain: B
Length: 131 amino acids
Theoretical weight: 15 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CDL 1 x CDL
Ligand PC1 2 x PC1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.51Å
Relevant EMDB volumes: EMD-34644
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

2 review citations

Ion and lipid orchestration of secondary active transport.
Drew et al. (2024)
1 more

2 mentions without citation

Cryo-electron microscopy-based drug design.
Cebi et al. (2024)
1 more