› 8hck

X-ray diffraction
2Å resolution

NMR fragment-based screening against the two PDZ do-mains of MDA-9

Released:
DOI: 10.2210/pdb8hck/pdb
PDB entry 8hck coloured by chain, front view.
PDB entry 8hck coloured by chain, side view.
PDB entry 8hck coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Tang H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126347 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Syntenin-1 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 8.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00560 (Residues: 113-191; Coverage: 27%)
Gene names: MDA9, SDCBP, SYCL
Sequence domains: PDZ domain

Ligands and Environments

3 bound ligands:
Ligand P1Z 1 x P1Z
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P4122
Unit cell:
a: 49.353Å b: 49.353Å c: 75.254Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.232 0.264
Expression system: Escherichia coli

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