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› 8hyb

X-ray diffraction
2.19Å resolution

Crystal structure of B1 IMP-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid

Released:
DOI: 10.2210/pdb8hyb/pdb
Model geometry
Fit model/data
PDB entry 8hyb coloured by chain, front view.
PDB entry 8hyb coloured by chain, side view.
PDB entry 8hyb coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Entry authors: Yan Y-H, Zhu K-R, Li G-B

Function and Biology Details

Reaction catalysed: 
a beta-lactam + H2O = a substituted beta-amino acid.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 219 amino acids
Theoretical weight: 24.21 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q79MP6 (Residues: 21-239; Coverage: 96%)
Gene names: bla IMP, bla-imp, blaESP, blaIMP-1, imp
Sequence domains: Metallo-beta-lactamase superfamily

Ligands and Environments

4 bound ligands:
Ligand ZN 8 x ZN
Ligand 5ZX 4 x 5ZX
Ligand ACT 4 x ACT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P21
Unit cell:
a: 48.899Å b: 201.103Å c: 52.319Å
α: 90° β: 89.97° γ: 90°
R-values:
R R work R free
0.178 0.177 0.227
Expression system: Escherichia coli BL21(DE3)

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