› 8i5d

X-ray diffraction
3.3Å resolution

Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)

Released:
DOI: 10.2210/pdb8i5d/pdb
Model geometry
Fit model/data
PDB entry 8i5d coloured by chain, front view.
PDB entry 8i5d coloured by chain, side view.
PDB entry 8i5d coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)
Lu D, Chen Y, Jiang M, Tan SG, Chai Y, Gao GF
Nat Commun (2023)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-279415 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
TCR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 21.43 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
TCR beta chain Chain: B
Molecule details ›
Chain: B
Length: 242 amino acids
Theoretical weight: 27.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Ig-like domain-containing protein Chain: H
Beta-2-microglobulin Chain: L
GTPase KRas, N-terminally processed Chain: P

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P6222
Unit cell:
a: 117.819Å b: 117.819Å c: 314.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.236 0.256
Expression systems:
  • Escherichia coli
  • Not provided

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