› 8ia5

X-ray diffraction
1.93Å resolution

Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX

Released:
DOI: 10.2210/pdb8ia5/pdb
PDB entry 8ia5 coloured by chain, front view.
PDB entry 8ia5 coloured by chain, side view.
PDB entry 8ia5 coloured by chain, top view.
Source organisms:
Entry authors: Cheng XY, Wei QY, Huang Y, Su ZD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127326 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
9-mer peptide Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.1 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand NUT 1 x NUT
Ligand O4B 1 x O4B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: P43212
Unit cell:
a: 47.08Å b: 47.08Å c: 90.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.284
Expression systems:
  • Escherichia coli
  • Not provided

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