› 8ibc

Electron Microscopy
3.6Å resolution

Respiratory complex CIII2, focus-refined of type IB, Wild type mouse under cold temperature

Released:
DOI: 10.2210/pdb8ibc/pdb
PDB entry 8ibc coloured by chain, front view.
PDB entry 8ibc coloured by chain, side view.
PDB entry 8ibc coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of respiratory complex adaptation to cold temperatures.
Shin YC, Latorre-Muro P, Djurabekova A, Zdorevskyi O, Bennett CF, Burger N, Song K, Xu C, Paulo JA, Gygi SP, Sharma V, Liao M, Puigserver P
Cell (2024)
PMID: 39395414
Related structures: EMD-35339

Function and Biology Details

Reaction catalysed: 
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 21-mer (preferred)
PDBe Complex ID:
PDB-CPX-271952 (preferred)
Entry contents:
10 distinct polypeptide molecules
Macromolecules (10 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chains: AA, Aa
Molecule details ›
Chains: AA, Aa
Length: 480 amino acids
Theoretical weight: 52.91 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9CZ13 (Residues: 1-480; Coverage: 100%)
Gene name: Uqcrc1
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chains: AB, Ab
Molecule details ›
Chains: AB, Ab
Length: 453 amino acids
Theoretical weight: 48.29 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q9DB77 (Residues: 1-453; Coverage: 100%)
Gene name: Uqcrc2
Sequence domains:
Cytochrome b Chains: AC, Ac
Cytochrome c1, heme protein, mitochondrial Chains: AD, Ad
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: AE, AI, Ae
Cytochrome b-c1 complex subunit 7 Chains: AF, Af
Cytochrome b-c1 complex subunit 8 Chains: AG, Ag
Cytochrome b-c1 complex subunit 6, mitochondrial Chains: AH, Ah
Cytochrome b-c1 complex subunit 9 Chains: AJ, Aj
Cytochrome b-c1 complex subunit 10 Chains: AK, Ak

Ligands and Environments

6 bound ligands:
Ligand HEM 4 x HEM
Ligand 3PE 2 x 3PE
Ligand U10 2 x U10
Ligand UQ6 2 x UQ6
Ligand HEC 2 x HEC
Ligand CDL 3 x CDL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.6Å
Relevant EMDB volumes: EMD-35339

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