› 8il7

X-ray diffraction
1.95Å resolution

Structure of human soluble Adenylyl Cyclase in complex with lactate

Released:
DOI: 10.2210/pdb8il7/pdb
Model geometry
Fit model/data
PDB entry 8il7 coloured by chain, front view.
PDB entry 8il7 coloured by chain, side view.
PDB entry 8il7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Lactate modulates iron metabolism by binding soluble adenylyl cyclase.
Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, Li Z, Shi Y, Hou Q, Ma J, Liu Y, Gao P, Ganz T, Liu S
Cell Metab 35 1597-1612.e6 (2023)
PMID: 37480842

Function and Biology Details

Reaction catalysed: 
ATP = 3',5'-cyclic AMP + diphosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate cyclase type 10 Chain: A
Molecule details ›
Chain: A
Length: 475 amino acids
Theoretical weight: 54.27 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96PN6 (Residues: 1-469; Coverage: 29%)
Gene names: ADCY10, SAC
Sequence domains: Adenylate and Guanylate cyclase catalytic domain

Ligands and Environments

2 bound ligands:
Ligand 2OP 1 x 2OP
Ligand GOL 3 x GOL
1 modified residue:
Ligand CME 1 x CME

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P63
Unit cell:
a: 99.28Å b: 99.28Å c: 98.564Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.164 0.163 0.188
Expression system: Trichoplusia ni

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Citations

3 review citations

Iron Absorption: Molecular and Pathophysiological Aspects.
Correnti et al. (2024)
2 more