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› 8jeo

X-ray diffraction
2.06Å resolution

Crystal structure of TIGIT in complexed with Tiragolumab

Released:
DOI: 10.2210/pdb8jeo/pdb
Model geometry
Fit model/data
PDB entry 8jeo coloured by chain, front view.
PDB entry 8jeo coloured by chain, side view.
PDB entry 8jeo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.
Sun J, Zhang X, Xue L, Cheng L, Zhang J, Chen X, Shen Z, Li K, Wang L, Huang C, Song J
Structure (2024)
PMID: 38460520

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274721 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
T-cell immunoreceptor with Ig and ITIM domains Chains: A, D
Molecule details ›
Chains: A, D
Length: 115 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q495A1 (Residues: 22-128; Coverage: 48%)
Gene names: TIGIT, VSIG9, VSTM3
Sequence domains: Immunoglobulin V-set domain
antibody heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 235 amino acids
Theoretical weight: 25.41 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
antibody light chain Chains: C, F

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: I4
Unit cell:
a: 214.161Å b: 214.161Å c: 66.885Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.206
Expression systems:
  • Escherichia coli
  • Homo sapiens

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