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› 8jrn

Electron Microscopy
2.6Å resolution

Structure of E6AP-E6 complex in Att1 state

Released:
DOI: 10.2210/pdb8jrn/pdb
PDB entry 8jrn coloured by chain, front view.
PDB entry 8jrn coloured by chain, side view.
PDB entry 8jrn coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into the functional mechanism of the ubiquitin ligase E6AP.
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
OpenAccess logo Nat Commun 15 3531 (2024)
PMID: 38670961
Related structures: EMD-36599

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptorprotein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-272187 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein E6 Chains: B, D
Molecule details ›
Chains: B, D
Length: 158 amino acids
Theoretical weight: 19.16 KDa
Source organism: Human papillomavirus 16
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P03126 (Residues: 1-158; Coverage: 100%)
Gene name: E6
Sequence domains: Early Protein (E6)
Ubiquitin-protein ligase E3A Chains: A, C
Molecule details ›
Chains: A, C
Length: 875 amino acids
Theoretical weight: 100.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05086 (Residues: 1-875; Coverage: 100%)
Gene names: E6AP, EPVE6AP, HPVE6A, UBE3A
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.6Å
Relevant EMDB volumes: EMD-36599
Expression system: Spodoptera frugiperda

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