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› 8k3t

Electron Microscopy
3.57Å resolution

S. cerevisiae Chs1 in complex with UDP

Released:
DOI: 10.2210/pdb8k3t/pdb
PDB entry 8k3t coloured by chain, front view.
PDB entry 8k3t coloured by chain, side view.
PDB entry 8k3t coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure, catalysis, chitin transport, and selective inhibition of chitin synthase.
Chen DD, Wang ZB, Wang LX, Zhao P, Yun CH, Bai L
OpenAccess logo Nat Commun 14 4776 (2023)
PMID: 37553334
Related structures: EMD-36859

Function and Biology Details

Reaction catalysed: 
[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-215832 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chitin synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1131 amino acids
Theoretical weight: 130 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P08004 (Residues: 1-1131; Coverage: 100%)
Gene names: CHS1, N1404, YNL192W
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand MG 4 x MG
Ligand UDP 2 x UDP
Ligand POV 2 x POV
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.57Å
Relevant EMDB volumes: EMD-36859
Expression system: Saccharomyces cerevisiae

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Citations

1 review citation

Innovations in Antifungal Drug Discovery among Cell Envelope Synthesis Enzymes through Structural Insights.
Zhou et al. (2024)
1 other article