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› 8kgp

Electron Microscopy
3.3Å resolution

Structure of African swine fever virus topoisomerase II in complex with dsDNA

Released:
DOI: 10.2210/pdb8kgp/pdb
PDB entry 8kgp coloured by chain, front view.
PDB entry 8kgp coloured by chain, side view.
PDB entry 8kgp coloured by chain, top view.
Source organism: African swine fever virus
Primary publication:
Structural insights into the DNA topoisomerase II of the African swine fever virus.
Cong J, Xin Y, Kang H, Yang Y, Wang C, Zhao D, Li X, Rao Z, Chen Y
Nat Commun 15 4607 (2024)
PMID: 38816407
Related structures: EMD-37229

Function and Biology Details

Reaction catalysed: 
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226598 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1211 amino acids
Theoretical weight: 138.09 KDa
Source organism: African swine fever virus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A0A2X0THW2 (Residues: 1-1192; Coverage: 100%)
Gene names: ASFV-Georgia_4-136, P1192R, P1192R CDS
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.3Å
Relevant EMDB volumes: EMD-37229
Expression system: Spodoptera frugiperda

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