› 8oi2

X-ray diffraction
3.3Å resolution

Crystal structure of Alb1 megabody in complex with human serum albumin

Released:
DOI: 10.2210/pdb8oi2/pdb
Model geometry
Fit model/data
PDB entry 8oi2 coloured by chain, front view.
PDB entry 8oi2 coloured by chain, side view.
PDB entry 8oi2 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross-reactive binding site.
De Felice S, Romanyuk Z, Chinellato M, Zoia G, Linciano S, Kumada Y, Pardon E, Steyaert J, Angelini A, Cendron L
OpenAccess logo Protein Sci 33 e4887 (2024)
PMID: 38152025

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242567 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Albumin Chain: A
Molecule details ›
Chain: A
Length: 581 amino acids
Theoretical weight: 66.21 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P02768 (Residues: 27-607; Coverage: 98%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Alb1 Megabody Chain: B
Molecule details ›
Chain: B
Length: 512 amino acids
Theoretical weight: 54.81 KDa
Source organism: Helicobacter pylori G27
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 370.359Å b: 73.819Å c: 66.13Å
α: 90° β: 96.9° γ: 90°
R-values:
R R work R free
0.228 0.226 0.277
Expression systems:
  • Komagataella pastoris
  • Escherichia coli

Quick links

Citations

1 mention without citation

Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross-reactive binding site.
De Felice et al. (2024)