› 8oiy

X-ray diffraction
2.1Å resolution

Crystal structure of the R15908H missense variant of titin domain Fn3-3

Released:
DOI: 10.2210/pdb8oiy/pdb
PDB entry 8oiy coloured by chain, front view.
PDB entry 8oiy coloured by chain, side view.
PDB entry 8oiy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure determination and analysis of titin A-band fibronectin type III domains provides insights for disease-linked variants and protein oligomerisation.
Rees M, Nikoopour R, Alexandrovich A, Pfuhl M, Lopes LR, Akhtar MM, Syrris P, Elliott P, Carr-White G, Gautel M
J Struct Biol 215 108009 (2023)
PMID: 37549721

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-227463 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 106 amino acids
Theoretical weight: 11.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8WZ42 (Residues: 14217-14319; Coverage: 0%)
Gene name: TTN
Sequence domains: Fibronectin type III domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 52.48Å b: 56.03Å c: 56.09Å
α: 60.06° β: 70.16° γ: 65.62°
R-values:
R R work R free
0.208 0.206 0.256
Expression system: Escherichia coli BL21

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