› 8p0z

X-ray diffraction
1.88Å resolution

AP01-S2.3 - a variant of a redesigned transferrin receptor apical domain

Released:
DOI: 10.2210/pdb8p0z/pdb
PDB entry 8p0z coloured by chain, front view.
PDB entry 8p0z coloured by chain, side view.
PDB entry 8p0z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding.
Sjöström DJ, Grill B, Ambrosetti E, Veetil AA, Mohlin C, Teixeira AI, Oberdofer G, Bjelic S
J Mol Biol 435 168262 (2023)
PMID: 37678707

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136210 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transferrin receptor protein 1, serum form Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 18.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02786 (Residues: 197-299, 332-377; Coverage: 20%)
Gene name: TFRC
Sequence domains: PA domain

Ligands and Environments

2 bound ligands:
Ligand NA 2 x NA
Ligand BO3 1 x BO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, DESY BEAMLINE P11
Spacegroup: P21
Unit cell:
a: 32.99Å b: 57.37Å c: 39.1Å
α: 90° β: 113.152° γ: 90°
R-values:
R R work R free
0.214 0.213 0.236
Expression system: Escherichia coli

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