› 8p4z

X-ray diffraction
2.75Å resolution

Crystal structure of the human CDK7 kinase domain in complex with LDC4297

Released:
DOI: 10.2210/pdb8p4z/pdb
Model geometry
Fit model/data
PDB entry 8p4z coloured by chain, front view.
PDB entry 8p4z coloured by chain, side view.
PDB entry 8p4z coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Laursen M, Caing-Carlsson R, Houssari R, Javadi A, Kimbung YR, Murina V, Orozco-Rodriguez JM, Svensson A, Welin M, Logan D, Svensson B, Walse B

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 304 amino acids
Theoretical weight: 34.37 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50613 (Residues: 10-311; Coverage: 87%)
Gene names: CAK, CAK1, CDK7, CDKN7, MO15, STK1
Sequence domains: Protein kinase domain

Ligands and Environments

4 bound ligands:
Ligand WZ8 2 x WZ8
Ligand GOL 8 x GOL
Ligand PGE 1 x PGE
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: MAX IV BEAMLINE BioMAX
Spacegroup: P4132
Unit cell:
a: 188.17Å b: 188.17Å c: 188.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.225 0.251
Expression system: Spodoptera frugiperda

Quick links